Proton-pump inhibitors could be innocent when used concomitantly with clopidogrel.

proton-pump inhibitor (PPI) is recommended for patients with a high risk of gastrointestinal bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs).1,2 PPIs utilize CYP2C19, a liver enzyme of cytochrome P450, for their inactivation, and this same enzyme mediates the generation of the active substance from the prodrug, clopidogrel, a platelet ADP… CONTINUE READING