Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites.

@article{Dam2016ProtonPI,
  title={Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites.},
  author={Gitte Aar\oe Dam and Hendrik Vilstrup and Hugh Watson and Peter Jepsen},
  journal={Hepatology},
  year={2016},
  volume={64 4},
  pages={1265-72}
}
UNLABELLED Proton pump inhibitors (PPIs) may be a risk factor for hepatic encephalopathy (HE) in patients with cirrhosis, possibly through translocation of gut bacteria, which can also lead to spontaneous bacterial peritonitis (SBP). We examined the associations between PPIs and development of HE or SBP in patients with cirrhosis with ascites. We used data from three 1-year trials of satavaptan for ascites control. We used Cox regression to compare HE and SBP rates between users and nonusers of… CONTINUE READING
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Hepatic Encephalopathy: An Update on the Pathophysiology and Therapeutic Options

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