Proton pump inhibitors are associated with increased risk of development of chronic kidney disease

  title={Proton pump inhibitors are associated with increased risk of development of chronic kidney disease},
  author={Pradeep Arora and Anu Gupta and Mojgan Golzy and Nilang Patel and Randolph L. Carter and Kabir Jalal and James W Lohr},
  booktitle={BMC nephrology},
BACKGROUND Acute interstitial nephritis secondary to proton pump inhibitors (PPIs) frequently goes undiagnosed due to its subacute clinical presentation, which may later present as chronic kidney disease (CKD). We investigated the association of PPI use with the development of CKD and death. METHODS Two separate retrospective case-control study designs were employed with a prospective logistic regression analysis of data to evaluate the association of development of CKD and death with PPI use… CONTINUE READING


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