Proton pump inhibitors and vascular function: A prospective cross-over pilot study.

@article{Ghebremariam2015ProtonPI,
  title={Proton pump inhibitors and vascular function: A prospective cross-over pilot study.},
  author={Yohannes T. Ghebremariam and John P Cooke and Fouzia Amir Khan and Rahul N Thakker and Peter D Chang and Nigam Haresh Shah and Kevin T. Nead and Nicholas J. Leeper},
  journal={Vascular medicine},
  year={2015},
  volume={20 4},
  pages={309-16}
}
Proton pump inhibitors (PPIs) are commonly used drugs for the treatment of gastric reflux. Recent retrospective cohorts and large database studies have raised concern that the use of PPIs is associated with increased cardiovascular (CV) risk. However, there is no prospective clinical study evaluating whether the use of PPIs directly causes CV harm. We conducted a controlled, open-label, cross-over pilot study among 21 adults aged 18 and older who are healthy (n=11) or have established clinical… CONTINUE READING
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