Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study.

@article{Antoniou2015ProtonPI,
  title={Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study.},
  author={Tony Antoniou and Erin M Macdonald and Simon Hollands and Tara Gomes and Muhammad M Mamdani and Amit X. Garg and John Michael Paterson and David N Juurlink},
  journal={CMAJ open},
  year={2015},
  volume={3 2},
  pages={E166-71}
}
BACKGROUND Proton pump inhibitors (PPIs) cause interstitial nephritis and are an underappreciated cause of acute kidney injury. We examined the risk of acute kidney injury and acute interstitial nephritis in a large population of older patients receiving PPIs. METHODS We conducted a population-based study involving Ontario residents aged 66 years and older who initiated PPI therapy between Apr. 1, 2002, and Nov. 30, 2011. We used propensity score matching to establish a highly comparable… CONTINUE READING

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