Proton-pump inhibitors and risk of fractures: an update meta-analysis

  title={Proton-pump inhibitors and risk of fractures: an update meta-analysis},
  author={B. Zhou and Y. Huang and H. Li and W. Sun and J. Liu},
  journal={Osteoporosis International},
  • B. Zhou, Y. Huang, +2 authors J. Liu
  • Published 2015
  • Medicine
  • Osteoporosis International
  • SummaryTo identify the relationship between proton-pump inhibitors (PPIs) and the risk of fracture, we conducted an update meta-analysis of observational studies. [...] Key MethodMethodsA systematic literature search up to February 2015 was performed in PubMed. We combined relative risks (RRs) for fractures using random-effects models and conducted subgroup and stratified analyses.ResultsEighteen studies involving a total of 244,109 fracture cases were included in this meta-analysis.Expand Abstract
    125 Citations
    An updated meta-analysis : the effect of proton pump inhibitor on risk of osteoporosis and fracture
    • Highly Influenced
    • PDF
    Proton-pump Inhibitor Use and Fracture Risk: An Updated Systematic Review and Meta-analysis
    • 27
    • PDF
    Calcium, proton pump inhibitors, and fracture risk
    • 11
    • Highly Influenced
    Proton pump inhibitors and fracture risk. The HUNT study, Norway
    • 4
    • PDF
    Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature


    Proton pump inhibitors therapy and risk of hip fracture: a systematic review and meta-analysis
    • 55
    • PDF
    Use of proton pump inhibitors and risk of osteoporosis-related fractures
    • 402
    • PDF
    Proton-pump inhibitor use and hip fractures in men: a population-based case-control study.
    • 44