Proton pump inhibitors and hypomagnesemia: a rare but serious complication.

@article{Perazella2013ProtonPI,
  title={Proton pump inhibitors and hypomagnesemia: a rare but serious complication.},
  author={Mark Anthony Perazella},
  journal={Kidney international},
  year={2013},
  volume={83 4},
  pages={553-6}
}
Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg(2+) absorption via transient receptor potential melastatin-6 and -7 (TRPM6/7). Danziger et al. confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center. They found that patients taking PPIs, compared with those receiving histamine-2 antagonists or no acid-suppressive medications, had a decline in serum Mg(2+) after adjusting for several clinical and laboratory factors… CONTINUE READING
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Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis . 1 . Oral absorption of magnesium

  • Bai JPF, E Hausman, R Lionberger, X Zhang
  • Mol Pharm advance online publication , 11 October
  • 2012

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