Proton-pump inhibitors: understanding the complications and risks

  title={Proton-pump inhibitors: understanding the complications and risks},
  author={P Malfertheiner and Arne Kandulski and Marino Venerito},
  journal={Nature Reviews Gastroenterology & Hepatology},
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. However, in the past decade, a steadily increasing list of complications following long-term use of PPIs has been reported. Their potent acid-suppressive action induces several structural and functional changes within the gastric mucosa, including fundic gland polyps, enterochromaffin-like cell hyperplasia and hypergastrinaemia, which can be exaggerated in the presence of… CONTINUE READING