Proton pump inhibitors: do differences in pharmacokinetics translate into differences in clinical outcomes?

@article{Fock2008ProtonPI,
  title={Proton pump inhibitors: do differences in pharmacokinetics translate into differences in clinical outcomes?},
  author={K M Fock and Tiing Leong Ang and Lean Choo Bee and Edmund Jon Deon Lee},
  journal={Clinical pharmacokinetics},
  year={2008},
  volume={47 1},
  pages={1-6}
}
Acid-related disorders are common management problems in clinical practice. The key to effective management is successful suppression of gastric acid production. Proton pump inhibitors (PPIs) are the most potent acid suppressants available and are significantly more effective than histamine H(2) receptor antagonists. Although PPIs are highly effective as a class, differences in their pharmacokinetics, such as bioavailability, elimination half-life and metabolism, may translate into differences… CONTINUE READING

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