Proton pump inhibitors: better acid suppression when taken before a meal than without a meal

@article{Hatlebakk2000ProtonPI,
  title={Proton pump inhibitors: better acid suppression when taken before a meal than without a meal},
  author={J. Hatlebakk and P. Katz and L. Camacho-Lobato and D. Castell},
  journal={Alimentary Pharmacology & Therapeutics},
  year={2000},
  volume={14}
}
Proton pump inhibitors including omeprazole and lansoprazole inhibit gastric acid secretion by selectively and non‐competitively inactivating the H+, K+ ATPase molecules of the parietal cell, but possibly only those that are actively secreting acid. This might imply that stimulation of acid secretion by a meal is necessary for optimal inhibition of gastric secretion. 
143 Citations
The effect of once daily omeprazole and succinic acid (VECAM) vs once daily omeprazole on 24‐h intragastric pH
  • 12
Optimising Acid Inhibition Treatment
  • 6
Control of gastric acid secretion in health and disease.
  • 363
  • PDF
Nocturnal acid breakthrough on proton pump inhibitor therapy: To treat or not to treat
  • 1
The pharmacology and clinical relevance of proton pump inhibitors
  • 12
Proton Pump Inhibitors in the Management of GERD
  • 27
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily
  • 178
Kinetics of the inhibition of food-stimulated secretion by ranitidine in dogs.
  • 8
The effect of food and antacids on lansoprazole absorption and disposition.
  • 50
...
1
2
...