Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis.

@article{Xu2015ProtonPI,
  title={Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis.},
  author={Hu Xu and Hong-jiang Wang and Chong-hui Li and Shan Ye and M S Dong and Qi-jun Xia and Ai-qun Zhang and K F Pan and Xinlan Ge and Jia Hong Dong},
  journal={Genetics and molecular research : GMR},
  year={2015},
  volume={14 3},
  pages={7490-501}
}
We used a meta-analysis approach to investigate the association between proton pump inhibitor (PPI) use and risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. We searched Ovid Medline, Embase, and the Cochrane Library to identify eligible studies. We included studies that compared cirrhotic patients who did or did not use PPIs. The primary outcome was SBP, and the secondary outcome was overall bacterial infection. Results were pooled using random-effect models. This process… CONTINUE READING
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