Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study.

@article{Robertson2007ProtonPI,
  title={Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study.},
  author={Douglas J. Robertson and Heidi Jeanet Larsson and S\oren Friis and Lars Pedersen and John A. Baron and Henrik Toft S\orensen},
  journal={Gastroenterology},
  year={2007},
  volume={133 3},
  pages={755-60}
}
BACKGROUND & AIMS Use of proton pump inhibitors (PPIs) has been associated with elevated levels of serum gastrin. Because hypergastrinemia increases colorectal mucosa proliferation and has been associated with risk of colorectal cancer (CRC) in human beings, we conducted a large population-based study in Denmark to assess whether PPI use is associated with CRC risk. METHODS We conducted the study in North Jutland County, Denmark. From the County Hospital Discharge Registry we identified… CONTINUE READING

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