Proton pump inhibitor treatment for acute peptic ulcer bleeding.

  title={Proton pump inhibitor treatment for acute peptic ulcer bleeding.},
  author={Grigoris I Leontiadis and Linda McIntyre and Virender Kumar Sharma and Colin W. Howden},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Peptic ulcer (PU) bleeding is associated with substantial morbidity, mortality and healthcare cost. Randomised controlled trials (RCTs) evaluating the clinical effect of proton pump inhibitors (PPIs) in peptic ulcer bleeding have yielded conflicting results. OBJECTIVES To evaluate the efficacy of PPIs in the management of acute bleeding from PU using evidence from RCTs. SEARCH STRATEGY We performed a search of CENTRAL, The Cochrane Library (Issue 3, 2003), MEDLINE (1966 to… CONTINUE READING
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