Corpus ID: 30412586

Proton-pump inhibitor therapy in patients with gastro-oesophageal reflux disease: putative mechanisms of failure.

@article{Fass2007ProtonpumpIT,
  title={Proton-pump inhibitor therapy in patients with gastro-oesophageal reflux disease: putative mechanisms of failure.},
  author={Ronnie Fass},
  journal={Drugs},
  year={2007},
  volume={67 11},
  pages={
          1521-30
        }
}
  • Ronnie Fass
  • Published in Drugs 2007
  • Medicine
  • Proton-pump inhibitor (PPI) failure in gastro-oesophageal reflux disease (GORD) patients has become the main reason for referral of these patients to gastroenterology specialists. It is estimated that 30% of GORD patients requiring a PPI once daily will experience treatment failure. Patients with non-erosive reflux disease are the most common GORD-related group in which once-daily PPI therapy fails. Various mechanisms have been suggested to underlie PPI failure in GORD patients. The most… CONTINUE READING

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