Proton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions

@inproceedings{Mermelstein2018ProtonPI,
  title={Proton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions},
  author={Joseph Mermelstein and Alanna Chait Mermelstein and Maxwell M. Chait},
  booktitle={Clinical and experimental gastroenterology},
  year={2018}
}
A significant percentage of patients with gastroesophageal reflux disease (GERD) will not respond to proton pump inhibitor (PPI) therapy. The causes of PPI-refractory GERD are numerous and diverse, and include adherence, persistent acid, functional disorders, nonacid reflux, and PPI bioavailability. The evaluation should start with a symptom assessment and may progress to imaging, endoscopy, and monitoring of esophageal pH, impedance, and bilirubin. There are a variety of pharmacologic and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 213 REFERENCES

Eosinophilic esophagitis: interactions with gastroesophageal reflux disease.

  • Gastroenterology clinics of North America
  • 2014
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Management of refractory typical GERD symptoms

  • Nature Reviews Gastroenterology &Hepatology
  • 2016
VIEW 16 EXCERPTS
HIGHLY INFLUENTIAL