Proton pump (H+/K+-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats.

@article{Pytlik2012ProtonP,
  title={Proton pump (H+/K+-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats.},
  author={Maria Pytlik and Urszula Cegieła and Joanna Folwarczna and Barbara Nowinska},
  journal={Pharmacological reports : PR},
  year={2012},
  volume={64 3},
  pages={
          625-34
        }
}
BACKGROUND Alendronate can induce esophagitis and stomach ulceration requiring the concurrent use of drugs which decrease HCl production. The aim of the present study was to investigate the effect of concurrent administration of proton pump inhibitors, omeprazole or pantoprazole, and alendronate on the mechanical properties of long bones in bilaterally ovariectomized (OVX) rats. METHODS The experiments were carried out on 3-month-old Wistar rats, divided into following groups: non… CONTINUE READING
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