Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain.

@article{Mader2002ProtonMR,
  title={Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain.},
  author={Irina Mader and U. Seeger and Jochen Karitzky and Michael Erb and Fritz Schick and Uwe Klose},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2002},
  volume={16 5},
  pages={538-46}
}
PURPOSE To quantify the macromolecular content in different anatomic brain regions and to evaluate an age dependency of the macromolecular concentrations. MATERIAL AND METHODS A short echo time Stimulated Echo Acquisition Mode (STEAM) sequence was used without and with inversion recovery metabolite nulling in 8-12 healthy volunteers. Quantitation was achieved by an extended LCModel, and macromolecular resonances at 0.9, 1.4, 2.1, and 3.0 ppm were evaluated. RESULTS In the cerebellum, the 1… CONTINUE READING