Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis.

@article{Matthews1991ProtonMR,
  title={Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis.},
  author={Paul M. Matthews and Gordon S. Francis and Jack P. Antel and Douglas L. Arnold},
  journal={Neurology},
  year={1991},
  volume={41 8},
  pages={1251-6}
}
We are investigating the potential of in vivo proton magnetic resonance spectroscopy for noninvasive characterization of the chemical pathology of plaques in magnetic resonance brain images from patients with multiple sclerosis. Spectra localized to chronic, irreversible plaques showed a decrease in the ratio of N-acetyl/creatine resonance intensities relative to normal-appearing white matter. Spectra localized to active plaques showed different metabolite changes as compared with spectra from… CONTINUE READING