Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy.

@article{Bernasconi2002ProtonMR,
  title={Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy.},
  author={Andrea Bernasconi and Edwin T Tasch and Fernando Cendes and Li Min Li and Douglas L. Arnold},
  journal={Progress in brain research},
  year={2002},
  volume={135},
  pages={
          297-304
        }
}
Whether temporal lobe epilepsy (TLE) is the result of an isolated, early injury or whether there is ongoing neuronal damage due to seizures is often debated. We attempted to examine the long-term effect of seizures using proton magnetic resonance spectroscopic imaging (1H-MRSI), which can quantify neuronal loss or dysfunction based on reduced signals from the neuronal marker N-acetylaspartate (NAA). We performed 1H-MRSI in 82 consecutive patients with medically intractable, non-foreign-tissue… CONTINUE READING
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