Proton magnetic resonance spectroscopic creatine correlates with creatine transporter protein density in rat brain.


Creatine (Cr) is an amino acid, which upon phosphorylation is utilized as an energy reservoir in cells with high-energy demand. The ongoing catabolism of creatine to creatinine requires a permanent creatine replenishment into the cells. Because neurons themselves cannot synthesize creatine, they have to take it up via the creatine transporter (CrT). Thus… (More)
DOI: 10.1016/j.jneumeth.2008.04.028