Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

@article{Traynelis1990ProtonIO,
  title={Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons},
  author={S. Traynelis and S. Cull-Candy},
  journal={Nature},
  year={1990},
  volume={345},
  pages={347-350}
}
MAMMALIAN neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspar-tate (NMDA) or aspartate, (S)-α-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate1. An important aspect of NMDA receptors is their regulation by a variety of factors such as glycine2, Mg2+ (refs. 3,4) and Zn2+ (refs 5,6) that are present in vivo. We show here that NMDA receptor responses are selectively inhibited by protons, with a 50% inhibitory… Expand
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