Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
@article{Traynelis1990ProtonIO, title={Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons}, author={Stephen F. Traynelis and Stuart G. Cull-Candy}, journal={Nature}, year={1990}, volume={345}, pages={347-350} }
MAMMALIAN neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspar-tate (NMDA) or aspartate, (S)-α-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate1. An important aspect of NMDA receptors is their regulation by a variety of factors such as glycine2, Mg2+ (refs. 3,4) and Zn2+ (refs 5,6) that are present in vivo. We show here that NMDA receptor responses are selectively inhibited by protons, with a 50% inhibitory…
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