• DOI:10.1038/345347A0
Corpus ID: 4351139

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

@article{Traynelis1990ProtonIO,
  title={Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons},
  author={S. Traynelis and S. Cull-Candy},
  journal={Nature},
  year={1990},
  volume={345},
  pages={347-350}
}

• S. Traynelis, S. Cull-Candy
• Published 1990
• Chemistry, Medicine
• Nature

MAMMALIAN neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspar-tate (NMDA) or aspartate, (S)-α-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate1. An important aspect of NMDA receptors is their regulation by a variety of factors such as glycine2, Mg2+ (refs. 3,4) and Zn2+ (refs 5,6) that are present in vivo. We show here that NMDA receptor responses are selectively inhibited by protons, with a 50% inhibitory… Expand

View on Springer

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed