Proton-induced phase separation in phosphatidylserine/phosphatidylcholine membranes.

  title={Proton-induced phase separation in phosphatidylserine/phosphatidylcholine membranes.},
  author={Satoru Tokutomi and Kazuo Ohki and Shunich Ohnishi},
  journal={Biochimica et biophysica acta},
  volume={596 2},
Effects of ph and ionic strength on phosphatidylserine/phosphatidylcholine mixed membranes prepared on Millipore filter pore surfaces have been studied using spin-labeled phosphatidylcholine. Lowering pH at constant ionic strength and lowering ionic strength at constant pH caused a lateral reorganization of the membrane. The trigger was protonation of the serine carboxyl group which caused solidification of phosphatidylserine molecules in the membrane, leaving a fluid phase consisting mainly of… CONTINUE READING

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