Proton-gated ion channels in cultured mouse cortical neurons.

@article{Varming1999ProtongatedIC,
  title={Proton-gated ion channels in cultured mouse cortical neurons.},
  author={Thomas Varming},
  journal={Neuropharmacology},
  year={1999},
  volume={38 12},
  pages={1875-81}
}
Proton-gated ion channels in cultured mouse cortical neurons were characterized using the patch clamp technique. In voltage clamp, rapid shifts of the extracellular saline from pH 7.4 to < 7.0 invariably triggered inward currents carried by sodium. The currents were inhibited by Amiloride (IC50: 6.2 microM). In current clamp, acidic saline depolarized the neurons and triggered trains of action potentials. Concentration-response experiments revealed an extreme intercell variance as the EC50… CONTINUE READING

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