Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data.

@article{Lear2003ProtonCT,
  title={Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data.},
  author={James D. Lear},
  journal={FEBS letters},
  year={2003},
  volume={552 1},
  pages={17-22}
}
The M2 proton channel from influenza A virus forms proton-selective ion channels, which are the target of the drug amantadine. Here, existing experimental data are quantitatively examined for insights into mechanisms to account for the pH- and voltage-dependences of M2 proton conduction. The analysis shows that a model involving protonation equilibria of His37, including pH-dependent changes in the relative rates of diffusion on either side of the pore, is quantitatively able to account for… CONTINUE READING

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