Proton conductance of influenza virus M2 protein in planar lipid bilayers.

@article{Vijayvergiya2004ProtonCO,
  title={Proton conductance of influenza virus M2 protein in planar lipid bilayers.},
  author={Viksita Vijayvergiya and Ryan Wilson and Adam Chorak and Philip Fei Gao and Timothy A. Cross and David D. Busath},
  journal={Biophysical journal},
  year={2004},
  volume={87 3},
  pages={1697-704}
}
Purified M2 protein from the Udorn strain of influenza virus was reconstituted into planar lipid bilayers from liposomes. In 1 mM HCl, the single-channel conductance was measured as 6 pS with open probability of < or =0.03. The current voltage curve is linear over the achievable voltage range. The current amplitude is amantadine sensitive. In HCl solutions, the single-channel current was essentially invariant with changes in [Cl(-)], [Na(+)], and [tetraethylammonium] ([TEA(+)]), but dependent… CONTINUE READING

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