Proton block of the CLC-5 Cl−/H+ exchanger

  title={Proton block of the CLC-5 Cl−/H+ exchanger},
  author={Alessandra Picollo and Mattia Malvezzi and Alessio Accardi},
  booktitle={The Journal of general physiology},
CLC-5 is a H(+)/Cl(-) exchanger that is expressed primarily in endosomes but can traffic to the plasma membrane in overexpression systems. Mutations altering the expression or function of CLC-5 lead to Dent's disease. Currents mediated by this transporter show extreme outward rectification and are inhibited by acidic extracellular pH. The mechanistic origins of both phenomena are currently not well understood. It has been proposed that rectification arises from the voltage dependence of a H… CONTINUE READING
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