Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.

@article{Lopes2000ProtonBA,
  title={Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.},
  author={Coeli M.B. Lopes and Patrick G Gallagher and Marianne E Buck and Margaret H. Butler and Steve A. N. Goldstein},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 22},
  pages={16969-78}
}
Potassium leak conductances were recently revealed to exist as independent molecular entities. Here, the genomic structure, cardiac localization, and biophysical properties of a murine example are considered. Kcnk3 subunits have two pore-forming P domains and unique functional attributes. At steady state, Kcnk3 channels behave like open, potassium-selective, transmembrane holes that are inhibited by physiological levels of proton. With voltage steps, Kcnk3 channels open and close in two phases… CONTINUE READING
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