• DOI:10.1002/cbdv.200800087
Corpus ID: 20543931

Proton Speciation and Microspeciation of Serotonin and 5‐Hydroxytryptophan

@article{Mazk2009ProtonSA,
  title={Proton Speciation and Microspeciation of Serotonin and 5‐Hydroxytryptophan},
  author={K. Maz{\'a}k and Veronika D{\'o}czy and J. K{\"o}k{\"o}si and B. Nosz{\'a}l},
  journal={Chemistry & Biodiversity},
  year={2009},
  volume={6}
}

K. Mazák, Veronika Dóczy, +1 author B. Noszál

Published 2009

Chemistry, Medicine

Chemistry & Biodiversity

Protonation equilibria of the neurotransmitter serotonin and its precursor 5-hydroxytryptophan (5-HTP) are characterized at the macroscopic and microscopic levels. 1H-NMR-pH and UV-pH titrations were carried out to determine the macroconstants. Microconstants were obtained by appropriate combination of interactivity parameters and model compounds, allowing the calculation of all the twelve microconstants, the eight microspecies concentrations, and three site-interactivity parameters of 5-HTP… CONTINUE READING

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