Proton Pump Inhibitors and Risk of Fracture: A Systematic Review and Meta-Analysis of Observational Studies

@article{Ngamruengphong2011ProtonPI,
  title={Proton Pump Inhibitors and Risk of Fracture: A Systematic Review and Meta-Analysis of Observational Studies},
  author={S. Ngamruengphong and G. Leontiadis and S. Radhi and A. Dentino and K. Nugent},
  journal={The American Journal of Gastroenterology},
  year={2011},
  volume={106},
  pages={1209-1218}
}
OBJECTIVES:Proton pump inhibitors (PPIs) are widely used in several acid-related gastrointestinal disorders. In vivo studies have suggested that gastric suppression by PPIs could result in decreased intestinal calcium absorption. Subsequently, there have been concerns that the chronic use of a PPI is associated with an increased risk of bone fracture. However, the results of clinical studies are conflicting.METHODS:We performed a systematic review and meta-analysis of controlled observational… Expand
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