Proton Pump Inhibitor and Clopidogrel Interaction: Fact or Fiction?

  title={Proton Pump Inhibitor and Clopidogrel Interaction: Fact or Fiction?},
  author={Loren Laine and Charles H. Hennekens},
  journal={The American Journal of Gastroenterology},
Current consensus recommendations state that patients prescribed clopidogrel plus aspirin should receive a proton pump inhibitor (PPI) to reduce gastrointestinal bleeding. Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. Clopidogrel users with decreased CYP2C19 function have less inhibition of platelet aggregation and increased cardiovascular (CV) events. As PPI metabolism also involves CYP2C19, it was hypothesized that competition by PPIs might interfere with… CONTINUE READING


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