Corpus ID: 858303

Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease.

@article{Lin2003ProtonMS,
  title={Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease.},
  author={D. Lin and T. Crawford and P. Barker},
  journal={AJNR. American journal of neuroradiology},
  year={2003},
  volume={24 1},
  pages={
          33-41
        }
}
PURPOSE AND BACKGROUND Mitochondrial diseases are a group of inherited disorders caused by a derangement of mitochondrial respiration. The clinical manifestations are heterogeneous, and the diagnosis is often based on information acquired from multiple levels of inquiry. MR spectroscopy has previously been shown to help detect an abnormal accumulation of lactate in brain parenchyma and CSF in association with mitochondrial disorders, but the frequency of detection is largely unknown. We sought… Expand
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TLDR
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[Aspect of brain MRI in mitochondrial respiratory chain deficiency. A diagnostic algorithm of the most common mitochondrial genetic mutations].
TLDR
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TLDR
MR imaging is helpful in the diagnosis of the classical mitochondrial diseases; however, nonspecific findings are common. Expand
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It is suggested that mitochondrial disorders should be evaluated in children presenting with a complex neurological picture or multisystem involvement, and not just in children with a single neurological symptom and other system involvement. Expand
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Although no one set of findings is diagnostic of these disorders, the combination of deep gray matter involvement and peripheral white matter involvement in young adults or children should suggest the diagnosis, especially when associated with an elevated lactate level on proton MRS. Expand
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TLDR
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TLDR
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TLDR
The diagnostic usefulness of the following physiological and imaging methods, which also offer functional information that can be used for follow-up, is critically assessed: lactate levels, exercise testing, phosphorus magnetic resonance spectroscopy, proton MRS, functional magnetic resonance imaging, positron emission tomography, optical tissue oximetry and single photon emissiontomography. Expand
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TLDR
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TLDR
It is suggested that proton MR spectroscopy may be more sensitive in the detection of MELAS-associated abnormalities than MR imaging, because it showed presence of lactate in all five cases studied, regardless of MR findings. Expand
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