Proton MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis.

@article{Brex1999ProtonMS,
  title={Proton MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis.},
  author={Peter A. Brex and Beatriz G{\'o}mez-Anson and Geoffrey J. M. Parker and Peter Molyneux and Katherine Anne Miszkiel and Gareth J. Barker and David G. MacManus and Charles A. Davie and Gordon T. Plant and David H. Miller},
  journal={Journal of the neurological sciences},
  year={1999},
  volume={166 1},
  pages={16-22}
}
The concentration of the metabolite N-acetyl aspartate (NAA), thought to be a marker of axonal loss or damage, has been shown to be reduced in lesions, as demonstrated by high signal areas on T2-weighted MRI, and in normal-appearing white matter (NAWM) in established multiple sclerosis (MS). The stage of the disease when these changes first appear is not known. To try to determine this we studied 20 patients with clinically isolated syndromes, many of whom will be at the earliest clinical… CONTINUE READING

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