Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy.


BACKGROUND AND PURPOSE MR imaging and MR spectroscopy are increasingly being used to determine response to pharmacologic therapy. Hepatic encephalopathy (HE) is characterized by abnormal cerebral metabolites, yet the response to lactulose and other anti-HE measures is still primarily determined by using arbitrary categorical clinical rating scales, rather… (More)


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