Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane

  title={Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane},
  author={Ikumi Tamai and Hitomi Takanaga and Hiroshi Maeda and Takuo Ogihara and Masaru Yoneda and Akira Tsuji},
  journal={Pharmaceutical Research},
Purpose. The purpose of the present study is to clarify the intestinal brush-border transport mechanism of a weak organic acid, pravastatin, an HMG-CoA reductase inhibitor. Methods. The transport of pravastatin was studied by using intestinal brush-border membrane vesicles prepared from rabbit jejunum, and uptake by the membrane vesicles was measured using rapid filtration technique. Results. The initial uptake of [14C]pravastatin was markedly increased with decreases in extravesicular pH and… CONTINUE READING