Proton Beams Inhibit Proliferation of Breast Cancer Cells by Altering DNA Methylation Status

  title={Proton Beams Inhibit Proliferation of Breast Cancer Cells by Altering DNA Methylation Status},
  author={Byungtak Kim and Hansol Bae and Hyunkyung Lee and Seungyeon Lee and Jeong Chan Park and Kye-Ryung Kim and Sun Jung Kim},
  journal={Journal of Cancer},
  pages={344 - 352}
Proton beam therapy has been gaining popularity in the management of a wide spectrum of cancers. However, little is known about the effect of proton beams on epigenetic alterations. In this study, the effects of proton beams on DNA methylation were evaluated in the breast cell lines MCF-10A and MCF-7. Pyrosequencing analysis of the long interspersed element 1 (LINE1) gene indicated that a few specific CpG sites were induced to be hypermethylated by proton beam treatment from 64.5 to 76.5% and… Expand
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