Proton/hydroxide conductance through phospholipid bilayer membranes: effects of phytanic acid.

@article{Gutknecht1987ProtonhydroxideCT,
  title={Proton/hydroxide conductance through phospholipid bilayer membranes: effects of phytanic acid.},
  author={John Gutknecht},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={898 2},
  pages={97-108}
}
Mechanisms of proton/hydroxide conductance (GH/OH) were investigated in planar (Mueller-Rudin) bilayer membranes made from decane solutions of phospholipids or phospholipids plus phytanic acid (a 20-carbon, branched chain fatty acid). At neutral pH, membranes made from diphytanoylphosphatidylcholine or bacterial phosphatidylethanolamine had GH/OH values in the range of (2-5) X 10(-9) S X cm-2, corresponding to H+/OH- 'net' permeabilities of about (0.4-1.0) X 10(-5) cm X s-1. GH/OH was inhibited… CONTINUE READING