Protocols for the Use of Cyproterone, Medroxyprogesterone, and Leuprolide in the Treatment of Paraphilia

@article{Reilly2000ProtocolsFT,
  title={Protocols for the Use of Cyproterone, Medroxyprogesterone, and Leuprolide in the Treatment of Paraphilia},
  author={Danelle Reilly and Nicholas John Delva and Robert W. Hudson},
  journal={The Canadian Journal of Psychiatry},
  year={2000},
  volume={45},
  pages={559 - 563}
}
Objective: To propose a protocol for minimizing medical complications associated with the use of cyproterone, medroxyprogesterone, and depot leuprolide to treat paraphilia. Method Review of the relevant literature. Results Certain patient populations should not be treated with these medications, and medical complications associated with each can be detected early and avoided. Conclusions For each drug, a series of screening tests prior to use and scheduled testing during use can minimize… 

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References

SHOWING 1-10 OF 94 REFERENCES

Effects of medroxyprogesterone on the liver function and drug metabolism of patients with primary biliary cirrhosis and chronic active hepatitis.

The results suggest that medroxyprogesterone may be a valuable alternative for patients with autoimmune liver disease, particularly in cases developing resistance or undesirable reactions to the previous therapy.

Influence of Medroxyprogesterone on Theophylline Disposition

The role of respiratory stimulants in the treatment of these diseases is of current interest and progesterone is recognized as a potent respiratory stimulant that causes hyperventilation resulting in lowered PaCO2 and elevated Pa02.

A Double-Blind Placebo Controlled Trial of Medroxyprogesterone Acetate and Cyproterone Acetate with Seven Pedophiles

The experience suggests that only a minority of pedophiles are likely to accept libido-reducing drugs, and the drugs, which performed equivalently, reduced sexual thoughts and fantasies, the frequency of early morning erections on awakening, thefrequency and pleasure of masturbation, and level of sexual frustration.

Medroxyprogesterone acetate does not induce antipyrine clearance and only weakly increases alpha 1-acid glycoprotein in beagle dogs.

The synthetic progestin medroxyprogesterone acetate has been shown to be an inducer of hepatic microsomal cytochrome P-450 in both man and the rat and was tested as a promoter of induction by combining it with a course of rifampin capable of substantially elevating both antipyrine clearance and AGP.

Pituitary apoplexy after leuprolide administration for carcinoma of the prostate

It is suspected that this acute stimulating effect of leuprolide is linked to the acute onset of pituitary apoplexy in a patient with a possible gonadotrophoma.

Cyproterone acetate in the treatment of sexual disorders: pharmacological base and clinical experience.

Cyproterone acetate (CPA) leads to loss of libido and the ability to achieve erection, followed by the inability to achieve orgasm, after about 14 days of treatment, and is generally well tolerated.

Effect of medroxy progesterone acetate and testosterone enanthate on vas deferens of rats.

Both types generated functional sterility in the rat, but MPA affected histophysiology of vasal tissue, resulting in reduced fertility.

Leuprorelin acetate blood levels and dialysance after the administration of sustained‐release leuprorelin acetate in a dialysis case complicated by prostate cancer

The objective of this study is to determine whether in a dialysis patient with prostate cancer leuprorelin acetate blood levels were abnormally high or low due to kidney failure or because of
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