Protocols for the Use of Cyproterone, Medroxyprogesterone, and Leuprolide in the Treatment of Paraphilia

  title={Protocols for the Use of Cyproterone, Medroxyprogesterone, and Leuprolide in the Treatment of Paraphilia},
  author={Danelle Reilly and Nicholas John Delva and Robert W. Hudson},
  journal={The Canadian Journal of Psychiatry},
  pages={559 - 563}
Objective: To propose a protocol for minimizing medical complications associated with the use of cyproterone, medroxyprogesterone, and depot leuprolide to treat paraphilia. Method Review of the relevant literature. Results Certain patient populations should not be treated with these medications, and medical complications associated with each can be detected early and avoided. Conclusions For each drug, a series of screening tests prior to use and scheduled testing during use can minimize… 

Clinical experience of the use of triptorelin as an antilibidinal medication in a high-security hospital

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Flutamide Induced Liver Injury in Female Patients

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Based upon the current literature, the finding of significant osteoporosis in two of four patients treated with CPA, but not those treated with leuprolide or castration, is surprising.

A Case of Mental Retardation with Paraphilia Treated with Depot Leuprorelin

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Flutamide-induced hepatotoxicity: ethical and scientific issues.

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Spontaneous reporting of hepatotoxicity associated with antiandrogens: data from the Spanish pharmacovigilance system

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Treatment of Paraphilic Sexual Offenders in Brazil: Issues and Controversies

In Brazil, the use of hormonal medications for the treatment of dangerous sexual offenders has been seen as amoral and insufficiently effective and safe, which creates many difficulties in the adequate management of sexual offenders in this country.

Drug treatment of paraphilic and nonparaphilic sexual disorders.

  • D. Guay
  • Medicine, Biology
    Clinical therapeutics
  • 2009



Effects of medroxyprogesterone on the liver function and drug metabolism of patients with primary biliary cirrhosis and chronic active hepatitis.

The results suggest that medroxyprogesterone may be a valuable alternative for patients with autoimmune liver disease, particularly in cases developing resistance or undesirable reactions to the previous therapy.

Influence of Medroxyprogesterone on Theophylline Disposition

The role of respiratory stimulants in the treatment of these diseases is of current interest and progesterone is recognized as a potent respiratory stimulant that causes hyperventilation resulting in lowered PaCO2 and elevated Pa02.

A Double-Blind Placebo Controlled Trial of Medroxyprogesterone Acetate and Cyproterone Acetate with Seven Pedophiles

The experience suggests that only a minority of pedophiles are likely to accept libido-reducing drugs, and the drugs, which performed equivalently, reduced sexual thoughts and fantasies, the frequency of early morning erections on awakening, thefrequency and pleasure of masturbation, and level of sexual frustration.

Medroxyprogesterone acetate does not induce antipyrine clearance and only weakly increases alpha 1-acid glycoprotein in beagle dogs.

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Pituitary apoplexy after leuprolide administration for carcinoma of the prostate

It is suspected that this acute stimulating effect of leuprolide is linked to the acute onset of pituitary apoplexy in a patient with a possible gonadotrophoma.

Cyproterone acetate in the treatment of sexual disorders: pharmacological base and clinical experience.

Cyproterone acetate (CPA) leads to loss of libido and the ability to achieve erection, followed by the inability to achieve orgasm, after about 14 days of treatment, and is generally well tolerated.

Effect of medroxy progesterone acetate and testosterone enanthate on vas deferens of rats.

Both types generated functional sterility in the rat, but MPA affected histophysiology of vasal tissue, resulting in reduced fertility.

Leuprorelin acetate blood levels and dialysance after the administration of sustained‐release leuprorelin acetate in a dialysis case complicated by prostate cancer

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