Protocol for seizure prophylaxis following intracerebral hemorrhage study (SPICH): a randomized, double-blind, placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute spontaneous supratentorial intracerebral hemorrhage.

@article{Hu2014ProtocolFS,
  title={Protocol for seizure prophylaxis following intracerebral hemorrhage study (SPICH): a randomized, double-blind, placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute spontaneous supratentorial intracerebral hemorrhage.},
  author={Xiuying Hu and Y Fang and Hua Li and Weiying Liu and S Lin and Min Fu and Xingang Li and Xinsheng Cao and Hongwei Zhang and Chao You and Ming Liu},
  journal={International journal of stroke : official journal of the International Stroke Society},
  year={2014},
  volume={9 6},
  pages={814-7}
}
RATIONALE Seizures after intracerebral hemorrhage are a common complication and may adversely affect neurological outcome. However, studies are inadequate on the utility of prophylactic anticonvulsant therapy in patients with hemorrhagic stroke, and the results remains controversial. AIMS This study aims to determine if short-duration sodium valproate prevents seizure onset or improves the survival and neurological outcome in adults after acute spontaneous supratentorial intracerebral… CONTINUE READING
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