This is a quantitative and qualitative research aimed at building a Welcome Protocol for users and their companions referred to the Endoscopic Centre at the University Hospital Dr. Polydoro Ernani São Thiago, at the Federal University of Santa Catarina (UFSC), and submitted to Upper Digestive Endoscopy. The research was elaborated in two stages. The first stage was the building of a collective protocol with a group of nurses; the second stage was the sending of this material, organized as a protocol, for validation by the three experts. The study's supporting theoretical background was the National Humanization Policy and the Basic Human Needs theory. The protocol built aims at detailing the procedures conducted in the pre, trans and post-endoscopy exam stages, permitting the organization of the service and the instrumentalization of the professional team and, thus, ensuring a safer welcome and service to the user and his/her companion.