Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]

@article{MartnezTorres2008ProtocolFG,
  title={Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]},
  author={Francisco J Mart{\'i}nez-Torres and Sanjay Menon and Maria Pritsch and Norbert Victor and Ekkehart Jenetzky and Katrin Jensen and Eva Schielke and Erich Schmutzhard and Jan de Gans and Chin-Hee Chung and Steffen P. Luntz and Werner Hacke and Uta Meyding-Lamad{\'e}},
  journal={BMC Neurology},
  year={2008},
  volume={8},
  pages={40 - 40}
}
BACKGROUND The treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major unsolved problem in Neurology. Current gold standard for therapy is acyclovir, a drug that inhibits viral replication. Despite antiviral treatment, mortality remains up to 15%, less than 20% of patients are able to go back to work, and the majority of patients suffer from severe disability. This is a discouraging, unsatisfactory situation for treating physicians, the disabled patients and their families, and… CONTINUE READING

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European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators: Dexamethasone in adults with bacterial meningitis

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