Protocol and Rationale-The Efficacy of Minocycline as an Adjunctive Treatment for Major Depressive Disorder: A Double Blind, Randomised, Placebo Controlled Trial

@inproceedings{Dean2014ProtocolAR,
  title={Protocol and Rationale-The Efficacy of Minocycline as an Adjunctive Treatment for Major Depressive Disorder: A Double Blind, Randomised, Placebo Controlled Trial},
  author={Olivia M Dean and Michael Maes and Melanie Maree Ashton and Lesley Berk and Buranee Kanchanatawan and Atapol Sughondhabirom and Sookjareon Tangwongchai and Chee H Ng and Nathan Dowling and Gin S. Malhi and Michael Berk},
  booktitle={Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology},
  year={2014}
}
While current pharmacotherapies are efficacious, there remain a clear shortfall between symptom remission and functional recovery. With the explosion in our understanding of the biology of these disorders, the time is ripe for the investigation of novel therapies. Recently depression is conceptualized as an immune-inflammatory and nitro-oxidative stress related disorder. Minocycline is a tetracycline antibiotic that has anti-inflammatory, pro-oxidant, glutamatergic, neurotrophic and… CONTINUE READING
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