Protochordate allorecognition is controlled by a MHC-like gene system

@article{Scofield1982ProtochordateAI,
  title={Protochordate allorecognition is controlled by a MHC-like gene system},
  author={Virginia Lee Scofield and Jay M. Schlumpberger and Leigh Ann West and Irving L. Weissman},
  journal={Nature},
  year={1982},
  volume={295},
  pages={499-502}
}
Colonial tunicates, unlike vertebrates, undergo transplantation in nature. Rejection or acceptance between colonies of Botryllus is controlled by a single gene locus with multiple alleles. The same genetic region apparently maintains this polymorphism by preventing fertilization between gametes sharing alleles. The Botryllus histocompatibility system may reflect the original adaptive function of ancestral MHC genes. 
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