Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway.

@article{Zhang2015ProtocatechuicAA,
  title={Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway.},
  author={Liang Zhang and Yunxia Ji and Zechun Kang and Chang-jun Lv and Wangling Jiang},
  journal={Toxicology and applied pharmacology},
  year={2015},
  volume={283 1},
  pages={50-6}
}
An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted from the degradation of phenolic acids. However, whether PA has anti-fibrotic functions is… CONTINUE READING