Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c‐Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice

@article{Park2016ProtocatechuicAA,
  title={Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c‐Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice},
  author={Sun-Hyang Park and Ju-Young Kim and Yoon-Hee Cheon and Jong Min Baek and Sung-Jun Ahn and Kwon-Ha Yoon and Myeung-Su Lee and Jaemin Oh},
  journal={Phytotherapy Research},
  year={2016},
  volume={30},
  pages={604 - 612}
}
Protocatechuic acid (PCA) plays a critical role in nutritional metabolism; it is a major metabolite of anthocyanins, which are flavonoids with a range of health benefits. PCA has a variety of biological activities including anti‐oxidant, antiinflammatory, anti‐apoptosis, and anti‐microbial activities. However, the pharmacological effect of PCA, especially on osteoclastogenesis, remains unknown. We examined the effect of PCA on receptor activator of NF‐κB ligand (RANKL)‐induced osteoclast… Expand
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