Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function

  title={Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function},
  author={Dimitar Kostadinov and Joshua R Sanes and Kang Shen},
Dendritic and axonal arbors of many neuronal types exhibit self-avoidance, in which branches repel each other. In some cases, these neurites interact with those of neighboring neurons, a phenomenon called self/non-self discrimination. The functional roles of these processes remain unknown. In this study, we used retinal starburst amacrine cells (SACs), critical components of a direction-selective circuit, to address this issue. In SACs, both processes are mediated by the gamma-protocadherins… CONTINUE READING
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