Protocadherin-19 is essential for early steps in brain morphogenesis.

  title={Protocadherin-19 is essential for early steps in brain morphogenesis.},
  author={Michelle R. Emond and Sayantanee Biswas and James D Jontes},
  journal={Developmental biology},
  volume={334 1},
One of the earliest stages of brain morphogenesis is the establishment of the neural tube during neurulation. While some of the cellular mechanisms responsible for neurulation have been described in a number of vertebrate species, the underlying molecular processes are not fully understood. We have identified the zebrafish homolog of protocadherin-19, a member of the cadherin superfamily, which is expressed in the anterior neural plate and is required for brain morphogenesis. Interference with… CONTINUE READING


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