Protocadherin γ-A7 is down-regulated in colorectal cancer and associated with the prognosis in patients with wild-type KRAS.

@article{Liu2019ProtocadherinI,
  title={Protocadherin γ-A7 is down-regulated in colorectal cancer and associated with the prognosis in patients with wild-type KRAS.},
  author={Yingdi Liu and Kangsheng Peng and Ruting Xie and J. Zheng and J. Guo and R. Wei and Huiqiong Yang and Chunmiao Cai and Q. Wei},
  journal={Human pathology},
  year={2019},
  volume={83},
  pages={
          14-21
        }
}
  • Yingdi Liu, Kangsheng Peng, +6 authors Q. Wei
  • Published 2019
  • Medicine
  • Human pathology
  • Many clustered protocadherin genes (PCDHs) within chromosome 5q31 are frequently down-regulated in colorectal cancer (CRC) due to the hypermethylation of this region, and some of them have been identified as tumor suppressors. However, the association between the expression of the clustered PCDHs and prognosis of CRC patients is still unclear. Here, we identified multiple PCDHs that were significantly down-regulated in CRC by analyzing the RNA-seq data of the Cancer Genome Atlas (TCGA) cohort… CONTINUE READING
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