Proto-oncogene transcription factors and epilepsy.

  title={Proto-oncogene transcription factors and epilepsy.},
  author={J. I. Morgan and Tom Curran},
  journal={Trends in pharmacological sciences},
  volume={12 9},
Chemically and electrically induced seizures elicit the rapid transcriptional activation in neurons of a class of genes referred to as cellular immediate-early genes. Since the products of these genes include transcription factors and cytokines, they are proposed to be involved in coupling neuronal excitation to a complex, and poorly understood, programme of cellular responses that involves the regulation of gene expression. Products of two cellular immediate-early genes, c-fos and c-jun, are… CONTINUE READING