Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes.

@article{Kruijer1986ProtooncogeneEI,
  title={Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes.},
  author={Wiebe Kruijer and H R Skelly and Florence Botteri and Herman van der Putten and Jack R. Barber and Inder M Verma and Hyam L Leffert},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 17},
  pages={7929-33}
}
Proto-oncogene fos mRNA levels are rapidly and transiently elevated 12-fold in regenerating liver 10-60 min following partial hepatectomy. This response, and the induction of fos protein synthesis, has been simulated qualitatively and quantitatively in long term primary cultures of quiescent adult rat hepatocytes where proliferative transitions can be initiated directly in serum-free medium by known hepatocyte mitogens like epidermal growth factor. Expression of a second proto-oncogene, c-rasH… CONTINUE READING
19 Citations
3 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-3 of 3 references

Animal Cell Proliferation

  • H. L. Leffert, K. S. Koch
  • Biochem. Biophys. Res. Commun
  • 1985

Nature 112 , 73 - 116 Mol

  • R. Muller, R. Bravo, J. Burckhardt, T. Curran
  • 1984

Cold Spring Harbor Symp

  • H. L. Leffert, K. S. Koch
  • Cell Prolif
  • 1982

Similar Papers

Loading similar papers…