Proto-oncogene c-erbB2 initiates rat primordial follicle growth via PKC and MAPK pathways

@inproceedings{Liping2010ProtooncogeneCI,
  title={Proto-oncogene c-erbB2 initiates rat primordial follicle growth via PKC and MAPK pathways},
  author={Zheng Li-ping and Zhang Da-lei and Huang Jian and Xu Liang-quan and Xu Ai-xia and Du Xiao-yu and Tang Dan-Feng and Zheng Yue-hui},
  booktitle={Reproductive biology and endocrinology : RB&E},
  year={2010}
}
BACKGROUND c-erbB2, a proto-oncogene coding epidermal growth factor receptor-like receptor, also as a chemosensitivity/prognosis marker for gynecologic cancer, may be involved in initiation of growth of rat primordial follicles. The aim of the present study is to investigate the role and signal pathway of c-erbB2 in onset of rat primordial follicle development. METHODS The expression of c-erbB2 mRNA and protein in neonatal ovaries cultured 4 and 8 days with/without epidermal growth factor… CONTINUE READING
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